Novel drugs targeting Toll-like receptors for antiviral therapy
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چکیده
منابع مشابه
Targeting Toll-Like Receptors for Treatment of SLE
Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic...
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Toll-like receptors (TLRs) are type I transmembrane proteins that are key regulators of both innate and adaptive immune responses. To protect the host from viral and bacterial threats, TLRs trigger a pro-inflammatory immune response by detecting pathogen and danger associated molecular patterns. Considerable evidence has accumulated to show that the dysregulation of TLR signaling contributes to...
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ژورنال
عنوان ژورنال: Future Virology
سال: 2014
ISSN: 1746-0794,1746-0808
DOI: 10.2217/fvl.14.70